Clinical Research Directory

Inclusion Criteria: * Being older than 18 years * Have rheumatoid arthritis or spondyloarthritis (ankylosing spondylitis, psoriatic arthritis) * Receive first conventional DMARD or biological treatment (anti-TNF, Abatacept, Tocilizumab, rituximab) for patients with rheumatoid arthritis * Receive biological treatment (Abatacept, Tocilizumab, rituximab) for patients with rheumatoid arthritis who have failed anti-TNF treatment. * Receive first NSAID (optionally combined with conventional DMARDs in case of peripheral arthritis) or biological treatment (anti-TNF, Usketinumab) for patients with spondyloarthritis. * Being subject to a social security scheme * Have the capacity to give informed consent and to comply with the study requirements Exclusion Criteria: * Patient refused to sign the consent form * Patient under guardianship * Patient having already been exposed to a biological as part of its pathology * Patient with chronic disease may interfere with cardiovascular disease either by itself or by treatment history * For echocardiography high resolution STI: Patients with hypertension, diabetes and cardiovascular history. * To evaluate the activity of the autonomic nervous system, patients with hypertension, diabetics, with cardiovascular history with a neurological disease, with vasoactive or chronotropic treatments such as beta-blockers, antiarrhythmics, antihypertensives, anxiolytics, antidepressants * Pregnant or lactating women will be temporarily excluded from the study during the period of pregnancy and breastfeeding.