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Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)
Sponsor: Wageningen University
Summary
The Alpha Omega Cohort is a prospective study of 4,837 state-of-the-art drug-treated Dutch patients aged 60-80 years who had a clinically diagnosed myocardial infarction up to 10 years before enrolment. During the first 40 months of follow-up, patients took part in an experimental study of low doses n-3 fatty acids (Alpha Omega Trial, ClinicalTrials.gov NCT00127452). At baseline (2002-2006), data on medical history, medication use, diet, lifestyle and other factors were collected by means of questionnaires. Patients were physically examined by trained research nurses and blood samples were obtained. Follow-up for vital status and cause-specific mortality is ongoing. The trial was approved by a central medical ethics committee (Haga Hospital, The Hague, The Netherlands) and all patients provided written informed consent.
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
4837
Start Date
2002-04
Completion Date
2040-01
Last Updated
2017-06-20
Healthy Volunteers
No
Conditions
Interventions
Dietary intake
Intake of nutrients, foods, food groups, beverages; dietary patterns.
Lifestyle factors
Physical activity; smoking; alcohol use; educational level.
Blood biomarkers
Biomarkers of dietary intake (e.g. fatty acids); biomarkers of disease.
Health
Current health status; medical history; medication use; self-rated health; risk factors for disease (e.g. body mass index, blood pressure, blood lipids, glucose)
DNA
SNPs (GWAS)
Mental well-being
Cognitive function; dispositional optimism; depression.
Locations (1)
Wageningen University, Division of Human Nutrition
Wageningen, Netherlands