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A Novel Multiplex ELISA Assay for Surveilling Patients With History of Bladder Cancer
Sponsor: Cedars-Sinai Medical Center
Summary
Voided urinary cytology (VUC) is the most widely used urine-based assay for detecting bladder cancer (BCa); however, it fails to detect approximately 50% of low-grade or early stage BCa when it is most curable. Furthermore, the detection rate of VUC for recurrent BCa is not much better. Because of this severe limitation, all patients who are under surveillance to monitor for recurrent BCa must undergo an invasive examination of the urinary bladder, where a miniature camera is inserted into the bladder and the bladder inspected (cystoscopy). We propose to improve the non-invasive detection of recurrent BCa by further validating a multiplex ELISA assay directed at a BCa-associated diagnostic signature in voided urine samples.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2016-12-30
Completion Date
2028-08
Last Updated
2026-02-04
Healthy Volunteers
No
Conditions
Locations (4)
Cedars-Sinai Medical Center
Los Angeles, California, United States
University of California San Francisco
San Francisco, California, United States
UT Southwestern Medical Center at Dallas
Dallas, Texas, United States
Kyoto University Graduate School of Medicine
Kyoto, Japan