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Augmentation of Limb Perfusion With Contrast Ultrasound
Sponsor: Oregon Health and Science University
Summary
Our laboratory has discovered that ultrasound (US) imaging together with clinically approved microbubble ultrasound contrast agents can augment limb tissue perfusion. These observations have been made in mice with and without peripheral artery disease (PAD), and also in humans where high power contrast enhanced ultrasound (CEU) was used to measure perfusion but was found also to augment perfusion by almost 2-fold. The latter human studies were performed with ultrasound protocols designed for perfusion imaging and not for flow augmentation. In this study, we will measure the degree to which limb perfusion is augmented with specific therapeutic CEU settings that are still within the FDA-approved limits with regards to US power and contrast dosing.
Key Details
Gender
All
Age Range
19 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2018-06-18
Completion Date
2019-12
Last Updated
2018-08-23
Healthy Volunteers
Yes
Conditions
Interventions
Ultrasound
Ultrasound exposure of Definity microbubbles infused over 10 min. Ultrasound administered at 1.3 MHz, mechanical index of 1.3, and pulsing interval of 10 s.
Locations (1)
OHSU
Portland, Oregon, United States