Clinical Research Directory

Inclusion Criteria: 1. Participants must be able to understand and provide written informed consent 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. All ethnic and gender groups will have equal access to the study 4. Incident adult (age ≥18) renal transplant patients with a living or deceased donor kidney transplant 5. Confirmed elevated urine CXCL10:Cr without a urinary tract infection or gross hematuria. Exclusion Criteria: 1. Primary non-function 2. Blood group (ABO) incompatible 3. Pre-transplant donor specific antibody (DSA) positive (MFI\>1000 OR positive flow crossmatch) 4. Human leukocyte (HLA) 0 HLA antigen D-related (DR) + 0 major HLA class 2 (DQ) mismatch 5. Presence of other transplanted organ or co-transplanted organ 6. Medical contraindication to biopsy or rejection treatment 7. Followed outside of investigational center 8. Participation in other interventional trials within 4-weeks post-transplant or anytime post-transplant till study end at 12-months 9. Intention to not use a maintenance immunosuppression regimen consisting of calcineurin inhibitor (CNI) and anti-proliferative agents 10. Any condition that, in the opinion of the investigator, would pose risk to the subject's safe participation, or interfere with their ability to comply with the study requirements, or may impact the quality of interpretation of the data.