Clinical Research Directory

Inclusion criteria: * Male and female patients with Cushing syndrome (CS) caused by ACTH-producing pituitary adenoma or cortisol producing adrenal adenoma * Age between 18 and 65 years Exclusion criteria * CS caused by ectopic ACTH producing tumours * CS caused by adrenocortical carcinoma * Pseudo CS * Subclinical CS * Exogenous CS * Previous history of major psychiatric disorder (not related to CS) * Neurological disorders affecting the central nervous system * High alcohol consumption (more than 14 units of alcohol per week) * Active malignancy or any treatment for malignancy during the last 2 years * Heart failure (NYHC II-IV) * Severe respiratory insufficiency * Severely impaired hepatic function (alanine transaminase and/or aspartate transaminase concentrations two times the upper limit of normal or above) * Severely impaired renal function (serum- creatinine \>150 µmol/L or glomerular filtration rate \<45 ml/min) * Pregnancy or breast feeding * Any other illness that significantly affects the patients cognitive function according to the investigators opinion * Contraindication for MRI (Presence of medical implants, metal in the body, claustrophobia)