Clinical Research Directory

Inclusion Criteria: i. Possession of one of the following criteria which places the patient at high risk for post-ERCP pancreatitis and/or if patient is to undergo a planned endoscopic intervention deemed at high risk: 1. Suspicion of Oddi dysfunction 2. Personal history of post-ERCP pancreatitis 3. More than 8 cannulation attempts 4. Precut sphincterotomy 5. Endoscopic papillary balloon dilation of an intact sphincter 6. Endoscopic pancreatic duct sphincterotomy 7. Ampullectomy 8. Total bilirubin \< 1.0 ii. Or possession of two or more of the following minor criteria: 1. Female sex 2. Age under 50 years 3. Personal history of recurrent acute pancreatitis 4. Pancreatic duct injection leading to "acinarization" or over 3 pancreatic duct injections 5. Pancreatic duct cytology acquisition Exclusion Criteria: 1. Patients aged less than 18 2. Inability to provide informed consent 3. Pregnancy 4. Active acute pancreatitis 5. Any contraindication to aggressive IVF hydration: evidence of clinical volume overload (peripheral or pulmonary edema), respiratory compromise (oxygen saturation \< 90% on room air), chronic kidney disease (creatinine clearance \< 40 mL/min), systolic congestive heart failure (ejection fraction \< 45%), cirrhosis, and severe electrolyte disturbance with sodium \<130 mEq/L or \>150 mEq/L 6. If patient does not undergo a planned high-risk intervention 7. If patient does not possess complete criteria which places them at high risk for post-ERCP pancreatitis 8. Patients with cholangitis 9. Patients with chronic and/or active pancreatitis 10. Patients with a true NSAID allergy 11. Patients greater than or equal to 75 years old