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Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
Sponsor: The Cleveland Clinic
Summary
To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.
Official title: Multiple Tracer Using Single Muscle Biopsy Technique in Evaluating Protein Synthesis and Break Down in Muscles of Cirrhotic Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2017-08-03
Completion Date
2027-09-30
Last Updated
2025-12-01
Healthy Volunteers
Not specified
Conditions
Interventions
blood draw and muscle biopsy
One venous catheter will be used for bolus injection of multiple labeled AA at the beginning .The second venous catheter will inserted in the other arm for 5 ml of arterialized venous blood draw.Following the infusions, a single muscle biopsy will be performed from the vastus lateralis of the thigh using the Bergstromm needle.
Locations (1)
Cleveland Clinic Foundation
Cleveland, Ohio, United States