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Oxytocin and Fetal Heart Rate Changes
Sponsor: Unyime Ituk
Summary
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.
Official title: A Randomized Controlled Trial Evaluating the Effect of the Oxytocin Infusion Rate on Fetal Heart Rate Changes and Maternal-Fetal Outcomes During the Initiation of Combined Spinal-Epidural Labor Analgesia
Key Details
Gender
FEMALE
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
730
Start Date
2019-02-20
Completion Date
2025-12-31
Last Updated
2025-06-04
Healthy Volunteers
Yes
Conditions
Interventions
Half dose Oxytocin
Patients randomized to the half dose oxytocin group will have the oxytocin infusion reduced to 50 % prior to placement of combined spinal epidural for labor analgesia
Locations (2)
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States