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Measurements of Water in Breath and Saliva
Sponsor: University of Colorado, Denver
Summary
This study proposes to demonstrate the feasibility of measuring 2H:1H and 18O:16O in saliva and breath by comparing the natural abundances of 2H:1H and 18O:16O in saliva and urine of un-dosed humans.
Official title: Rapid Measurements of Water Isotopes in Human Breath and Saliva for Doubly Labeled Water Analysis
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2018-02-27
Completion Date
2026-12
Last Updated
2025-12-19
Healthy Volunteers
Yes
Conditions
Interventions
Feasibility of measuring 2H:1H and 18O:16O in saliva and breath.
The investigators propose to demonstrate the feasibility of measuring 2H:1H and 18O:16O in saliva and breath. The natural abundances of 2H:1H and 18O:16O of urine, saliva, and breath samples will be determined from samples obtained simultaneously from 50 relatively healthy human subjects. We will also measure 2H:1H and 18O:16O enrichments in urine, saliva, and breath of 10 relatively healthy human subjects obtained after consuming a standard DLW dose and compare the estimates of TDEE using these different matrices.
Locations (1)
Edward Melanson
Aurora, Colorado, United States