Retinal Imaging in Neurodegenerative Disease

RECRUITING

NCT03233646

Sponsor: Duke University

Summary

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Official title: Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

2000

Start Date

2017-07-20

Completion Date

2026-12-31

Last Updated

2026-02-04

Healthy Volunteers

Yes

Conditions

Alzheimer's Disease Mild Cognitive Impairment Parkinson's Disease Multiple Sclerosis Huntington Disease Lewy Body Dementia Frontotemporal Dementia Amyotrophic Lateral Sclerosis (ALS)APOE-4 Positive Traumatic Brain Injury Concussion Post-Traumatic Stress Disorder Down Syndrome Neuro-Degenerative Disease Normal Cognition

Interventions

DEVICE

Retinal and Choroidal Imaging

Non-invasive OCT, OCTA, and UWF fundus photography of retina

Locations (1)

Duke University Medical Center

Durham, North Carolina, United States

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