Clinical Research Directory

Inclusion criteria: * Age: 18 to 65 (inclusive) * Gender: both males and females * Body mass index (BMI): 18.5-34.9 kg/m2 * Habitual sleep duration \<7 hours and voluntary prolongation of sleep when circumstances allow (as indicated by napping and/or \>45 min catch-up sleep during weekends or holidays) * Presence of prehypertension (office systolic BP (SBP) 120-139 mmHg and/or diastolic BP (DBP) 80-89 mmHg) , Stage 1 hypertension (office SBP 140-159 mmHg and/or DBP 90-99 mmHg ) , or currently taking antihypertensive medications * Either on no prescription medications (other than oral contraceptive pills, or intrauterine devices) or on stable medical regimen for at least 1 month, if taking prescription medications for chronic conditions * Not pregnant or breast feeding and not intending to become pregnant or breast feed * Not a current smoker or tobacco user * Ability to provide written informed consent. Exclusion criteria: * Vulnerable study populations will be excluded * Pregnancy * Smoking * Shift-work * Travel across \>2 time zones in the previous month * Presence of overt cardiovascular diseases, diabetes, chronic kidney disease, cancer, sleep/circadian disorders, psychiatric disorders * If taking prescription medications for chronic conditions, change in therapy (type, frequency and/or dosage) over the previous month * Sleep aids * Habitual sleep duration ≥7 hours * Excessive alcohol (\>14 drinks/week in men and \>7 drinks/week in women) and/or excessive caffeine intake (\>400 mg) * Currently on a diet and/or actively trying to lose weight * History of drowsing driving * Severe daytime sleepiness (score \>15 at the Epworth Sleepiness Scale) * Current or previous (during the past 2 months) participation in other research studies at the discretion of study personnel * Blood/plasma donation during the past 2 months * Unwillingness or inability to adjust sleep schedule