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Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)
Sponsor: Scientific Institute San Raffaele
Summary
Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study. Aim of the study is to evaluate the patients' haemostatic and coagulation profile, how it interacts with the support device as well as the effect of antithrombotic drugs. From these data, it will be possible to derive the mechanisms triggering post-implant thromboembolic/hemorrhagic complications and to identify potential therapeutic targets.
Official title: Analysis of the Platelet Activity State in Patients Implanted With Ventricular Assist Device (VAD)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2017-06-29
Completion Date
2026-12-31
Last Updated
2025-05-15
Healthy Volunteers
Yes
Conditions
Interventions
PAS assay, TGT
Evaluation of platelet function
Locations (1)
San Raffaele Scientifc Institute - Cardiothoracic Intensive Care Unit
Milan, MI, Italy