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EUS-GE vs ES for Palliation of Gastric Outlet Obstruction
Sponsor: Johns Hopkins University
Summary
Gastric outlet obstruction (GOO) is a common complication of luminal malignancies which is associated with substantial morbidity. Palliation of GOO has traditionally been through the surgical bypass of the obstructed lumen by creating an opening between the stomach and small intestine. However, In recent years, a less invasive approach, i.e. endoscopic stenting, has gained wide acceptance to treat unresectable malignant gastric outlet obstruction. In this study, the investigators are going to compare the safety and efficacy of the two different endoscopic techniques including Endoscopic ultrasonography-guided gastroenterostomy (EUS-GE) and enteral stenting (ES).
Official title: EUS-guided Gastroenterostomy Versus Enteral Stenting for Palliation of Malignant Gastric Outlet Obstruction: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
112
Start Date
2020-10-26
Completion Date
2026-01-15
Last Updated
2026-07-06
Healthy Volunteers
No
Conditions
Interventions
Lumen-apposing metal stent
In this technique, the gastric wall and its adjacent small intestine are punctured by a needle to make a connection between the stomach and small intestine. Then a lumen-apposing metal stent is deployed at the puncture site to keep the stomach-small intestine connection open.
Self-expandable metal stent
In this technique, under endoscopic visualization, a guidewire will be advanced through the obstructed part of the stomach. Then an enteral self-expandable metal stent will be deployed under direct endoscopic visualization and fluoroscopic guidance.
Locations (9)
Yale University
New Haven, Connecticut, United States
The Johns Hopkins Hospital
Baltimore, Maryland, United States
Wake Forest Baptist University
Winston-Salem, North Carolina, United States
The Research Institute of McGill University Health Centre
Montreal, Quebec, Canada
Ecuadorian Institute of Digestive Diseases (IECED)
Guayaquil, Ecuador
Hospital Prive des Peupliers
Paris, France
Asian Institute of Gastroenterology
Hyderabad, India
Emek Medical Center
Afula, Israel
Hospital Universitario Rio Hortega
Valladolid, Spain