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RECRUITING
NCT03259867
PHASE2

Combination of TATE and PD-1 Inhibitor in Liver Cancer

Sponsor: Teclison Ltd.

View on ClinicalTrials.gov

Summary

This is a multi-center, open-label phase IIA study that investigates the preliminary efficacy of Trans-arterial Tirapazamine Embolization (TATE) treatment of liver cancer followed by a PD-1 checkpoint inhibitor (nivolumab). Patients with two types of cancers will be enrolled, advanced hepatocellular carcinoma (HCC),and metastatic gastric cancer. All enrolled patients need to have liver lesions and have progressed on a prior immune checkpoint inhibitor.

Official title: Phase IIA Single-Arm Study of Treatment of Patients With Advanced Liver Cancer With a Combination of TATE (Transarterial Tirapazamine Embolization) Followed by an Anti-PD-1 Monoclonal Antibody

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

54

Start Date

2017-07-01

Completion Date

2025-12-31

Last Updated

2024-11-22

Healthy Volunteers

No

Interventions

DRUG

Nivolumab Injectable Product

a PD-1 immune check inhibitor

COMBINATION_PRODUCT

Trans-arterial tirapazamine embolization

Embolization with Lipiodol and Gelfoam

Locations (3)

University of California, Irvine

Orange, California, United States

University of Oklahoma Health Science Center

Oklahoma City, Oklahoma, United States

Medical College of Wisconsin

Milwaukee, Wisconsin, United States