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Combination of TATE and PD-1 Inhibitor in Liver Cancer
Sponsor: Teclison Ltd.
Summary
This is a multi-center, open-label phase IIA study that investigates the preliminary efficacy of Trans-arterial Tirapazamine Embolization (TATE) treatment of liver cancer followed by a PD-1 checkpoint inhibitor (nivolumab). Patients with two types of cancers will be enrolled, advanced hepatocellular carcinoma (HCC),and metastatic gastric cancer. All enrolled patients need to have liver lesions and have progressed on a prior immune checkpoint inhibitor.
Official title: Phase IIA Single-Arm Study of Treatment of Patients With Advanced Liver Cancer With a Combination of TATE (Transarterial Tirapazamine Embolization) Followed by an Anti-PD-1 Monoclonal Antibody
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2017-07-01
Completion Date
2025-12-31
Last Updated
2024-11-22
Healthy Volunteers
No
Conditions
Interventions
Nivolumab Injectable Product
a PD-1 immune check inhibitor
Trans-arterial tirapazamine embolization
Embolization with Lipiodol and Gelfoam
Locations (3)
University of California, Irvine
Orange, California, United States
University of Oklahoma Health Science Center
Oklahoma City, Oklahoma, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States