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Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)
Sponsor: Incyte Corporation
Summary
The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat compared to sunitinib or pazopanib in participants with locally advanced/metastatic renal cell carcinoma (mRCC) with a clear cell component who have not received prior systemic therapy for their mRCC.
Official title: A Randomized, Open-Label, Phase 3 Study to Evaluate Efficacy and Safety of Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care (Sunitinib or Pazopanib) as First-Line Treatment for Locally Advanced or Metastatic Renal Cell Carcinoma (mRCC) (KEYNOTE-679/ECHO-302)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
129
Start Date
2017-12-07
Completion Date
2025-06-04
Last Updated
2026-05-22
Healthy Volunteers
No
Conditions
Interventions
Pembrolizumab
Pembrolizumab 200 mg administered intravenously every 3 weeks.
Epacadostat
Epacadostat 100 mg administered orally twice daily.
Sunitinib
Sunitinib 50 mg administered orally once daily; 4 weeks on, 2 weeks off for 6-wk cycle.
Pazopanib
Pazopanib 800 mg administered orally once daily.
Locations (140)
Pinnacle Oncology Hematology
Scottsdale, Arizona, United States
Scottsdale Healthcare
Scottsdale, Arizona, United States
Arizona Oncology Associates PC- HOPE
Tucson, Arizona, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
UC Irvine Comprehensive Cancer Center/Chao Family Comprehensive Cancer Center
Orange, California, United States
UC Davis Comprehensive Cancer Center
Sacramento, California, United States
Woodlands Medical Specialists, PA
Pensacola, Florida, United States
Northside Hospital
Atlanta, Georgia, United States
Atlanta Cancer Care - Conyers
Conyers, Georgia, United States
Northwest Georgia Oncology Centers Pc
Marietta, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Southeast Nebraska Hematology & Oncology Consultants, P.C.
Lincoln, Nebraska, United States
New York Oncology Hematology P.C
Albany, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Levine Cancer Institute
Charlotte, North Carolina, United States
Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, United States
University of Tennessee Erlanger Oncology & Hematology
Chattanooga, Tennessee, United States
The West Clinic, P.C.
Germantown, Tennessee, United States
US Oncology and Research
The Woodlands, Texas, United States
Utah Cancer Specialists
Salt Lake City, Utah, United States
Huntsman Cancer Institute
Salt Lake City, Utah, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Roanoke, Virginia, United States
Shenandoah Oncology, P.C.
Winchester, Virginia, United States
Canberra Hospital
Garran, Australian Capital Territory, Australia
Calvary Mater Newcastle
Waratah, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
Cabrini Health
Malvern, Victoria, Australia
Fiona Stanley Hospital
Murdoch, Australia
Centro de pesquisa Porto Alegre
Porto Alegre, Florianopolis, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos
Barretos, São Paulo, Brazil
Instituto do Cancer de Sao Paulo - ICESP
São Paulo, São Paulo, Brazil
Hospital Sao Jose
São Paulo, São Paulo, Brazil
Centro Avancado de Tratamento Oncologico - CENANTRON -
Belo Horizonte, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil
Tom Baker Cancer Centre
Calgary, Alberta, Canada
Kingston Health Sciences Centre - KGH Site
Kingston, Ontario, Canada
Sunnybrook Health Sciences, Odette Cancer Centre
Toronto, Ontario, Canada
Jewish General Hospital
Montreal, Quebec, Canada
CHU de Quebec-Universite Laval-Hotel Dieu de Quebec
Québec, Quebec, Canada
CIUSSS de la Mauricie-et-du-Centre-du-Quebec
Trois-Rivières, Quebec, Canada
Clinica Alemana de Osorno
Osorno, Los Lagos Region, Chile
Fundacion Arturo Lopez Perez FALP
Santiago, Chile
Pontificia Universidad Catolica de Chile
Santiago, Chile
Hospital Clinico Vina del Mar
Viña del Mar, Chile
Centre Antoine Lacassagne
Nice, Cedex 2, France
CHU Besancon - Hopital Jean Minjoz
Besançon, France
Hopital Saint Andre
Bordeaux, France
Centre Francois Baclesse
Caen, France
Hopital Prive Toulon Hyeres Sainte Marguerite
Hyères, France
Hopital Europeen Georges Pompidou
Paris, France
Hospices Civils de Lyon Centre Hospitalier Lyon Sud
Pierre-Bénite, France
Clinique Sainte Anne
Strasbourg, France
CHU de Strasbourg - Nouvel Hopital Civil
Strasbourg, France
Institut Gustave Roussy
Villejuif, France
Helios Klinikum Berlin Buch
Berlin, Germany
Universitaetsklinikum der Technischen Universitaet Dresden
Dresden, Germany
Universitaetsklinikum Essen
Essen, Germany
Universitaetsklinikum Frankfurt
Frankfurt am Main, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitaetsklinikum Jena
Jena, Germany
Universitaetsklinikum Magdeburg. Klinik fuer Urologie
Magdeburg, Germany
Universitaetsklinikum Tuebingen
Tübingen, Germany
Orszagos Onkologiai Intezet
Budapest, Pest County, Hungary
Zala Megyei Szent Rafael Korhaz
Zalaegerszeg, Pozva, Hungary
Somogy Megyei Kaposi Mor Oktato Korhaz
Kaposvár, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, Hungary
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet
Szolnok, Hungary
Markusovszky Egyetemi Oktatokorhaz
Szombathely, Hungary
Adelaide & Meath Hospital
Dublin, Ireland
University Hospital Waterford
Waterford, Ireland
Medical Oncology Ospedale San Donato
Arezzo, Italy
Azienda Ospedaliera-Spedali Civili
Brescia, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
A.O. Cardarelli
Naples, Italy
Policlinico San Matteo
Pavia, Italy
Azienda Ospedaliera San Camillo Forlanini
Roma, Italy
Nagoya University Hospital
Nagoya, Aichi-ken, Japan
National Cancer Center Hospital East
Kashiwa, Chiba, Japan
Sapporo Medical University Hospital
Sapporo, Hokkaido, Japan
Hokkaido University Hospital
Sapporo, Hokkaido, Japan
Nara Medical University Hospital
Kashihara, Nara, Japan
Kindai University Hospital
Sayama, Osaka, Japan
Saitama Medical University International Medical Center
Hidaka, Saitama, Japan
Yamaguchi University Hospital
Ube, Yamaguchi, Japan
Akita University Hospital
Akita, Japan
Kyushu University Hospital
Fukuoka, Japan
Niigata University Medical & Dental Hospital
Niigata, Japan
Toranomon Hospital
Tokyo, Japan
Nippon Medical School Hospital
Tokyo, Japan
Keio University Hospital
Tokyo, Japan
Auckland City Hospital
Auckland, Grafton, New Zealand
Helse Bergen HF Haukeland sykehus
Bergen, Norway
Sykehuset Oestfold
Grålum, Norway
Sorlandet sykehus HF
Kristiansand, Norway
Akershus University Hospital
Lørenskog, Norway
Oslo universitetssykehus
Oslo, Norway
Universitetssykehuset i Nord Norge. Kreftavdelingen
Tromsø, Norway
St Olavs Hospital
Trondheim, Norway