Clinical Research Directory

Inclusion Criteria: * Age 18 or older. * Crohn's disease diagnosed based on standard objective methodology (clinical, biochemical, endoscopic, histological and radiological correlation). * Active disease based on Harvey Bradshaw Index (HBI \>5) and elevated C-reactive protein (CRP) (\>normal reference range for local laboratory) OR fecal calprotectin (FCP) (\>250 µg/g) * Due to commence treatment with ADAL. Exclusion Criteria: * Severe co-existing cardiopulmonary, hepatic, renal, neurologic, or rheumatologic disease. * History of active HIV, hepatitis B or C infection, * Patients with ileostomy/colostomy, ileal-pouch anal anastomosis or severe perianal fistulising disease. * Pregnancy * Prior exposure to ADAL