Healthy Volunteers
Inclusion Criteria:
* Subjects must be ≥21 and ≤80 years of age;
* Subjects must provide informed consent prior to study procedures;
Exclusion Criteria:
* Known structural heart disease (e.g. myocardial infarction);
* History of ventricular arrhythmia;
* Any contraindication to MRI and/or PET, including:
* Subjects with life vest;
* Subjects with implanted heart device (e.g. ICD, Pacemaker);
* Subjects with metallic fragment or foreign body;
* Subjects with other form of devices or prosthesis that are not MRI compatible, such as insulin pump, joint replacement, hearing aid, cochlear implant, permanent contraceptive devices, etc.;
* Claustrophobia;
* Relative or absolute contraindication to Dotarem contrast:
* history of renal disease including acute or chronic severe renal insufficiency (glomerular filtration rate \<60 mL/min/1.73m2);
* a history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic fibrosis, and other co-morbidities;
* History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent
* Any clinically significant acute or unstable physical or psychological disease, judged by the investigators based on medical history or screening physical examination, to be incompatible with the study;
* Any physical or psychological disease judged by the investigators to be incompatible with the study, based on medical history or screening physical examination
* Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months);
* Female subjects only: Positive serum and/or urine pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
* Inability to provide written informed consent;
Arrhythmia Subjects:
Inclusion criteria
* Subjects must be ≥21 and ≤80 years of age;
* Subjects must provide informed consent prior to study procedures;
* History of scar-mediated ventricular arrhythmia scheduled for invasive EAM-guided catheter ablation for clinical care
Exclusion criteria
* Any contraindication to MRI and/or PET, including:
* Subjects with life vest;
* Subjects with implanted heart device (e.g. ICD, Pacemaker);
* Subjects with metallic fragment or foreign body;
* Subjects with other form of devices or prosthesis that are not MRI compatible, such as insulin pump, joint replacement, hearing aid, cochlear implant, permanent contraceptive devices, etc.;
* Claustrophobia;
* Relative or absolute contraindication to Dotarem contrast:
* history of renal disease including acute or chronic severe renal insufficiency (glomerular filtration rate \<60 mL/min/1.73m2);
* history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic fibrosis, and other co-morbidities;
* History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent;Any clinically significant acute or unstable physical or psychological disease, judged by the investigators based on medical history or screening physical examination, to be incompatible with the study;
* Any physical or psychological disease judged by the investigators to be incompatible with the study, based on medical history or screening physical examination
* Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months);
* Female subjects only: Positive serum and/or urine pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
* Inability to provide written informed consent;
