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Heart Failure and Aortic Stenosis Transcriptome
Sponsor: IRCCS Policlinico S. Donato
Summary
This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.
Official title: Study of the Transcriptomic Alterations in Heart Failure and Aortic Stenosis
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2016-05-30
Completion Date
2027-12-31
Last Updated
2025-04-30
Healthy Volunteers
No
Conditions
Interventions
measurement of RNAs
Locations (2)
Irccs Policlinico San Donato
San Donato Milanese, Milan, Italy
Ospedale San Raffaele
Milan, Italy