Clinical Research Directory

Inclusion Criteria: * Radically resected colon cancer patients with adeno- or signet ring cell carcinomas with high-risk tumors defined as: perforated / pT4NanyM0 (UICC 8th edition) / pTanyNanyM1 with radically resected PM including ovarian metastases * Performance status 0-1 * Fertile women must use approved contraceptives (see below) * Age \> 18 years * Written informed consent Exclusion Criteria: * Radiologically or clinically proven relapse. * Previous cytoreductive surgery (CRS) with HIPEC * Other malignant diagnosis within the last 2 years * Contraindications to laparoscopy (e.g. severe adhesions, peritonitis) * A history of allergic reaction to oxaliplatin or other platinum containing compounds * Renal impairment, defined as GFR \< 50 ml/min, (Cockcroft-Gault Equation). * Myocardial insufficiency, defined as NYHA class \> 2. * Impaired liver function defined as bilirubin ≥ 1.5 x UNL (upper normal limit). * Inadequate haematological function defined as ANC ≤ 1.5 x 109/l and platelets ≤ 100 x 109/l. * Any other condition or therapy, which in the investigator's opinion may pose a risk to the patient or interfere with the study objectives.