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ASCT With Nivolumab in Patients With Multiple Myeloma
Sponsor: St. Petersburg State Pavlov Medical University
Summary
This is an open-label, single center trial of Autologous Stem Cell Transplantation (ASCT) with nivolumab in multiple myeloma patients to determine the efficacy and safety of ASCT and PD1 inhibitor combination. For this purpose, 30 multiple myeloma patients, who have received induction therapy and have achieved a partial response (PR), stable disease (SD) or progression, and thus have unfavorable prognosis, will be treated with nivolumab administered iv at a dose of 100 mg on days 3 before and 17 after high-dose melphalan with autologous stem cell transplantation.
Official title: Autologous Stem Cell Transplantation With Nivolumab in Patients With Multiple Myeloma
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2017-04-24
Completion Date
2024-12-30
Last Updated
2024-05-07
Healthy Volunteers
No
Conditions
Interventions
Melphalan
iv infusion 70-100 mg/m2 on day -3, -2
Nivolumab
iv infusion 100 mg on day -3, +17
Autologous Stem Cell Transplantation
peripheral blood stem cell transfusion at day 0
Locations (1)
Boris V Afanasyev, MD, Prof.
Saint Petersburg, Russia