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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
Sponsor: St. Louis University
Summary
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Official title: Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: A Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2018-05-03
Completion Date
2028-01
Last Updated
2025-10-15
Healthy Volunteers
Yes
Conditions
Interventions
Zoledronic Acid
4 mg of zoledronic acid (Zometa) will be added to each bag of bone cement
Locations (16)
University of California - Los Angeles
Los Angeles, California, United States
Indiana University
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
University of Kansas
Overland Park, Kansas, United States
Johns Hopkins University Hospital
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Boston Children's Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Saint Louis University
St Louis, Missouri, United States
Wake Forest University
Winston-Salem, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
University of Oklahoma
Oklahoma City, Oklahoma, United States
Allegheny-Singer Research Institute
Pittsburgh, Pennsylvania, United States
University of Washington
Seattle, Washington, United States
McGill University Health Centre
Montreal, Quebec, Canada
All India Institute of Medical Science
New Delhi, India