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The Effects of the Female Hormones on Cerebral Perfusion
Sponsor: University Ghent
Summary
Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other brain parameters (grey matter, resting-state brain activity, brain connectivity and white matter diffusion) caused by the female sex hormones and hormonal contraception.
Official title: The Effects of the Female Sex Hormones and Hormonal Contraception on Cerebral Perfusion
Key Details
Gender
FEMALE
Age Range
18 Years - 25 Years
Study Type
OBSERVATIONAL
Enrollment
62
Start Date
2016-10-03
Completion Date
2027-12-31
Last Updated
2023-12-06
Healthy Volunteers
Yes
Interventions
MRI scan
Several MRI scan modalities: MPRAGE (structural scan), arterial spin labeling (cerebral perfusion), resting state functional-MRI (fMRI, cerebral activity) and diffusion MRI (white matter diffusion and white matter tracts).
Physiological monitoring
During MRI: heart rate, end-tidal carbon dioxide (CO2), respiratory rate and skin conductance
Blood sample
Blood sample after MRI-session: measurement of hematocrit, hemoglobin, estradiol, progesterone, follicle stimulation hormone and luteinizing hormone.
Blood pressure measurement
Measuring blood pressure before and after MRI-scan
Body temperature
Measuring body temperature before and after MRI-scan
Questionnaires
Questionnaires at the start of the study on lifestyle. Additionally, a questionnaire before each scan session on the actual state of the volunteer (e.g. mood, caffeine consumption, alcohol, medication, etc.)
Pregnancy test
Test for pregnancy using a pregnancy dipstick test
Locations (1)
Ghent University Hospital
Ghent, Belgium