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NCT03300882

PREDICT Cytomegalovirus (CMV)

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

View on ClinicalTrials.gov

Summary

The overall objective of this study is to establish a personalized test to measure individualized cytomegalovirus (CMV) specific immunity in lung transplant recipients in an effort to guide antiviral prophylaxis duration in clinical practice. Targeted participants are those: * enrolled in clinical research study CTOT-20 (Clinical Trials.gov ID: NCT02631720) who * are CMV recipient positive by serology as determined using methods in accordance with current local organ procurement organization policies.

Official title: Prospective Multicenter Cytomegalovirus (CMV) Specific Immune Monitoring to Predict Patient Risk After Lung Transplantation (CTOT-22)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

84

Start Date

2017-10-31

Completion Date

2019-11-25

Last Updated

2026-09-25

Healthy Volunteers

No

Conditions

Interventions

OTHER

Procedure

Serial blood draws. Participants will be enrolled either pre-transplant or within 45 days post-transplant and will be followed over the course of 18 months post transplant. Protocol mandated serial measurement of cytomegalovirus (CMV)-specific immune signature will occur pre-transplant (as applicable) and at post-transplant timepoint months 2, -3, -6, -9, -12 and -18.

Locations (4)

Johns Hopkins Hospital: Transplantation

Baltimore, Maryland, United States

Duke University Medical Center: Transplantation

Durham, North Carolina, United States

Cleveland Clinic Foundation: Transplantation

Cleveland, Ohio, United States

Toronto General Hospital: Transplantation

Toronto, Canada