Clinical Research Directory

Inclusion Criteria: * Adults ≥ 18 years old * Prevalent (≥ 6 months after kidney transplantation) kidney transplant recipients * eGFR (CKD-EPI formula) between 10 and 50 ml/min/1.73 m² * Patient has provided informed consent prior to initiation of any study related procedure Exclusion Criteria: * Allergy to sodium bicarbonate or any component of Nephrotrans®, namely soy or peanuts (reported cross-reactivity to peanuts has been reported in patients with soy-allergy). * Unstable clinical condition (e.g. uncontrolled heart failure, clinical uremia, uncontrolled hypertension, impending initiation of dialysis treatment…) as judged by the recruiting physician * Pregnant and nursing (lactating) women * Unwillingness to discontinue current medication with sodium bicarbonate * Unwillingness to discontinue antacids containing aluminum, calcium carbonate, magnesium, lactate, citrate, bicarbonate or mixtures thereof