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Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)
Sponsor: Population Health Research Institute
Summary
The prevention of perioperative atrial fibrillation (AF) and myocardial injury after non-cardiac surgery (MINS) has the potential to reduce mortality, stroke, and hospital stays in patients undergoing major thoracic surgery. Data from cardiac surgery patients suggest that prevention of perioperative atrial fibrillation using an anti-inflammatory agent, such as colchicine, is feasible. The COP-AF trial will assess whether the administration of oral colchicine will reduce the incidence of perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery.
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3209
Start Date
2018-02-14
Completion Date
2023-06-23
Last Updated
2026-10-16
Healthy Volunteers
No
Interventions
Active Colchicine
Oral colchicine 0·5 mg twice daily, starting within 4 h before surgery and continuing for 10 days.
Active Placebo
Oral placebo 0·5 mg twice daily, starting within 4 h before surgery and continuing for 10 days.
Locations (46)
Cleveland Clinic Florida
Weston, Florida, United States
Henry Ford Hospital
Detroit, Michigan, United States
Stony Brook University Hospital
Stony Brook, New York, United States
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
Fairview Hospital
Cleveland, Ohio, United States
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States
Rhode Island Hospital
Providence, Rhode Island, United States
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Vienna General Hospital
Vienna, Austria
CHU Brugmann UVC
Brussels, Brussels Capital, Belgium
Hôpital Érasme
Brussels, Belgium
Hôpital Civil Marie Curie
Charleroi, Belgium
Foothills Medical Centre
Calgary, Alberta, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
Health Sciences Centre Winnipeg
Winnipeg, Manitoba, Canada
Victoria General Hospital
Halifax, Nova Scotia, Canada
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
Victoria Hospital
London, Ontario, Canada
The Ottawa Hospital General Campus
Ottawa, Ontario, Canada
Toronto General Hospital
Toronto, Ontario, Canada
St. Joseph's Health Centre
Toronto, Ontario, Canada
Montreal General Hospital
Montreal, Quebec, Canada
Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Quebec, Canada
CIUSSS de l'Estrie - CHUS
Sherbrooke, Quebec, Canada
Fundación Cardioinfantil y LaCardio
Bogotá, Cundinamarca, Colombia
Prince of Wales Hospital
Hong Kong, Hong Kong, Hong Kong
Tuen Mun Hospital
Hong Kong, Hong Kong
Azienda Ospedaliero Universitaria Careggi
Florence, Florence, Italy
Ospedale Santa Maria della Misericordia
Udine, Udine, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS
Roma, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea
Rome, Italy
Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino
Torino, Italy
Hospital Serdang
Kajang, Selangor, Malaysia
University of Malaya Medical Centre
Kuala Lumpur, Selangor, Malaysia
Shifa International Hospital
Islamabad, Islamabad, Pakistan
Hospital del Mar
Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Universitari Sagrat Cor
Barcelona, Spain
Hospital Vall d'Hebron
Barcelona, Spain
Hospital Clínic de Barcelona
Barcelona, Spain
Hospital Gregorio Maranon
Madrid, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Luzerner Kantonsspital
Lucerne, Switzerland
Universitätsspital Zürich
Zurich, Switzerland