Inclusion Criteria:
Patients must meet all of the following items at the time of case registration:
1. Patients with infiltrative breast cancer, aged ≥20 years, meeting the following definitions:
* Those pathologically diagnosed with stage I, II, or IIIA breast cancer (Cancer Management Regulations, 11th version)
* Those who underwent appropriate surgery, such as mastectomy and breast-preserving surgery
2. Estrogen receptor (ER)- or progesterone receptor (PgR)-positive patients on immunohistochemical (IHC) staining
3. Females meeting one of the following criteria for menopause:
* Those, aged ≥55 years, without menstruation
* Those, aged \<55 years, with amenorrhea for ≥12 months, or those diagnosed with menopause by attending physicians based on the FSH and estradiol levels
* Those who underwent bilateral oophorectomy
4. Patients in whom the BMD for the lumbar vertebrae (L1-L4) on DXA before the start of this study is ≥-1.0SD of the mean value of young adult females (YAM), and the BMD for the femoral neck is ≥-1.0SD of YAM
5. Patients without lumbar vertebral or femoral fracture
6. Those with an ECOG PS of 0-2
7. Those with adequate organ functions (laboratory data within 4 weeks before case registration)
* Leukocyte count, ≥3,000/mm3 or Neutrophil count, ≥1,500/mm3
* AST, ALT, ≤1.5-fold of the upper limit of the institutional reference range
* Serum creatinine, ≤1.5-fold of the upper limit of the institutional reference range
8. Case registration should be performed before the following point:Twelve weeks after the completion of surgery or postoperative chemotherapy (The completion of chemotherapy refers to the completion of the final course, involving the recovery phase.)
9. Patients with an interval of ≥4 weeks after the discontinuation of therapy with bisphosphonates (oral preparations), estrogen preparations, raloxifene, calcitonin preparations, vitamin K preparations, active vitamin D preparations, or ipriflavone preparations, which influence bones
10. Those from whom written informed consent regarding study participation was obtained
Exclusion Criteria:
Whether each patient meets any of the following items must be checked on case registration:
1. Patients in whom distant metastasis was confirmed clinically or using imaging procedures at the time of case registration
2. Those with bilateral breast cancer
3. Those for whom postoperative hormonal therapy was started before consenting to study participation
4. Those who received endocrine therapy within 52 weeks before consenting to study participation
5. Those to whom bisphosphonate preparations were intravenously administered within 52 weeks before consenting to study participation
6. Those with the following diseases that may affect DXA
* Severe scoliosis, immobility, hyperostosis or osteosclerosis of the lumbar vertebrae, calcification of the abdominal aorta, and vertebral disease
7. Those with a history of malignant tumors other than breast cancer within 260 weeks before consenting to study participation
8. Those with dental diseases, such as infectious diseases of the teeth or jaw and tooth trauma. Those for whom tooth or jaw surgery is scheduled within 6 weeks after consenting to study participation (tooth extraction, implantation)
9. Others who are considered to be ineligible by the chief investigator
