Clinical Research Directory

Inclusion criteria for BD subjects: * ages 18-60 years (inclusive) and able to give voluntary informed consent; * Satisfy criteria for Diagnostic and Statistical Manual 5th edition (DSM-V) for BD I or II, current Depressive Episode; * 17-item Hamilton Depression Rating Scale (HAM-D) score \>15 and \<25; * Young Mania Rating Scale (YMRS) \< 8; * no psychotropics in the last 2 weeks (if previously on fluoxetine then medication free for 5 weeks) OR on stable psychotropic medications for 12 weeks * no lithium treatment for past 6 months; * satisfy criteria to undergo an MRI scan based on MRI screening questionnaire; * able to be managed as outpatients during the study as ascertained by Clinical Global Severity Scale \< 5 (i.e., moderately ill) and no significant suicidal or homicidal ideation or gross disability. Exclusion criteria for BD subjects are: * meeting DSM-IV criteria for schizophrenia, schizoaffective disorder, or an anxiety disorder as * a primary diagnosis; * requiring inpatient treatment; * meeting DSM-V criteria for substance dependence within the past 3 months, except caffeine or nicotine; * positive urinary toxicology screening at screening visit; * use of alcohol in the past 1 week; * serious medical or neurological illness; * current pregnancy or breast feeding; * metallic implants or other contraindications to MRI. Inclusion criteria for healthy subjects: * ages 18-60 years and ability to give voluntary informed consent; * no history of psychiatric illness or substance abuse or dependence; * no significant family history of psychiatric or neurological illness in first degree relative; * not currently taking any prescription or centrally acting medications; * no use of alcohol in the past 1 week; * and no serious medical or neurological illness. Exclusion criteria for healthy subjects are: * under 18 years of age; * pregnant or breast-feeding; * metallic implants or other contraindication to MRI.