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The Effects of Different Anesthetics on Functional Connectivity
Sponsor: Beijing Tiantan Hospital
Summary
This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.
Official title: The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)
Key Details
Gender
MALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2017-04-01
Completion Date
2025-12-31
Last Updated
2024-08-01
Healthy Volunteers
Yes
Conditions
Interventions
Midazolam
Midazolam was administered intravenously at a dose of 0.1 mg / kg followed by continuous intravenous injection at 0.03 mg / kg / h and maintained until the course of the scan.
Propofol
Propofol group 1mg / kg intravenous injection, followed by 2mg / kg / h continuous intravenous injection, and maintained to the scanning process;
Dexmedetomidine
Dexmedetomidine group with total amount of 1μg / kg, infusion time 15min, followed by 0.6μg / kg / h, and maintained to the scanning process;
Locations (1)
Beijing Tian Tan Hospital
Beijing, China