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Assessing Neurocognition After Cerebrovascular Intervention
Sponsor: University of California, San Diego
Summary
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2021-07-15
Completion Date
2025-12
Last Updated
2025-02-06
Healthy Volunteers
No
Interventions
Neurocognitive Assessments
Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis. Prior to surgery patients will undergo a battery of neurocogntive assessments 1 month and 2 months prior to surgery.
Measurements of inflammatory biomarkers
Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis. After surgery, patients will undergo blood draws to measure for inflammatory biomarkers.
Carotid Artery Stenting
Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis.
Locations (1)
UCSD Medical Center
San Diego, California, United States