Clinical Research Directory

Inclusion Criteria: * Chronic, mature clonal B-cell malignancy that is not assignable to a specific WHO category by current technology (see flowchart in section below). Exclusion Criteria: * Non-clonal B-cell proliferation. * High grade and/or immature clonal B-cell malignancy. * Bone marrow samples with less than 20% infiltration will be excluded * Samples from patients with a known classifiable chronic B-LPD based on lymph node biopsy for e.g. staging bone marrow samples on a patient with marginal zone lymphoma. If a definitive diagnosis is established on a subsequent lymph node biopsy, patient will remain on study and this will be correlated with NGS findings. * Patient unable to provide consent for tumour and germ line samples.