Clinical Research Directory

Inclusion Criteria: 1. Diagnosis of Beta Thalathemia. 2. Age: ≥ 4 years. 3. Karnofsky: ≥ 80%. 4. Left ventricular ejection fraction (LVEF): \> 50%; no obvious heart disease and pulmonary hypertension. 5. Pulmonary function is normal; forced expiratory volumein one second (FEV1) and vital capacity greater than 60% and DLCO \> 50%. 6. Serum creatinine ≤ 2 × upper limit of normal range. 7. MRI showed no super-iron load in the heart and liver, and no severe cirrhosis. 8. Normal Coagulation. 9. Written, informed consent obtained prior to any study-specific procedures. Exclusion Criteria: 1. Diagnosis of active malignant disease (other than Bowen disease or cervical cancer); or has family history of cancer. 2. Myelopathy, tumor-related cytogenetic changes or other more severe blood diseases. 3. Has alcoholism experience within 6 months prior to enrollment. 4. History of epilepsy. 5. History of bone marrow transplantation. 6. Existence of an available HLA-identical related donor. 7. Pregnant or lactating females. 8. Subject infected with HIV (HIV antibody positive), Treponema pallidum antibody positive or TB culture positive. 9. Patients, in the opinion of investigators, may not be eligible or not able to comply with the study.