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Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation
Sponsor: Central Hospital, Nancy, France
Summary
The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2019-10-01
Completion Date
2026-09-30
Last Updated
2019-10-14
Healthy Volunteers
No
Interventions
Blood Sample
Additional blood sample before graft, D0, D7, D15, D21, D30, D60, D90, D180, Y1, Y2
Bone marrow aspiration
Additional bone marrow aspiration before graft, D30, D90, Y1
Blood sample
Before donation
Allogeneic hematopoietic stem cell sample
Allogeneic hematopoietic stem cell sample
Locations (1)
CHRU de Nancy
Vandœuvre-lès-Nancy, France