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Zimura Compared to Sham in Patients With Autosomal Recessive Stargardt Disease (STGD1)
Sponsor: Astellas Pharma Global Development, Inc.
Summary
The purpose of this study is to evaluate the safety and efficacy of avacincaptad pegol intravitreal injection compared to Sham in participants with autosomal recessive Stargardt disease 1 (STGD1).
Official title: A Phase 2b Randomized, Double-masked, Controlled Trial to Establish the Safety and Efficacy of Zimura™ (Complement C5 Inhibitor) Compared to Sham in Subjects With Autosomal Recessive Stargardt Disease
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
121
Start Date
2018-01-12
Completion Date
2025-03-31
Last Updated
2026-04-15
Healthy Volunteers
No
Conditions
Interventions
avacincaptad pegol
Intravitreal Injection
Sham
Intravitreal Injection
Locations (41)
Retinal Research Institute
Phoenix, Arizona, United States
Jules Stein Eye Institute/ David Geffen School of Medicine
Los Angeles, California, United States
VitreoRetinal Associates
Gainesville, Florida, United States
Retina Specialty Institute
Pensacola, Florida, United States
Wilmer Eye Institute, Johns Hopkins
Baltimore, Maryland, United States
Ophthalmic Consultants of Boston
Boston, Massachusetts, United States
University of Michigan/Kellogg Eye Center
Ann Arbor, Michigan, United States
The Retina Center
Minneapolis, Minnesota, United States
Retina Center of NJ, LLC.
Bloomfield, New Jersey, United States
Casey Eye Institute/Oregon Health & Science University
Portland, Oregon, United States
Wills Eye Hospital/Mid Atlantic Retina
Philadelphia, Pennsylvania, United States
UPMC Eye Center
Pittsburgh, Pennsylvania, United States
Palmetto Retina Center
West Columbia, South Carolina, United States
Austin Retina Associates
Austin, Texas, United States
Retina Foundation of the Southwest
Dallas, Texas, United States
Strategic Clinical Research Group
Willow Park, Texas, United States
University of Utah John A. Moran Eye Center
Salt Lake City, Utah, United States
Hopital de la Croix-Rousse
Lyon, Auvergne-Rhône-Alpes, France
Creteil University Eye Clinic University Paris EST
Créteil, France
Centre ophtalmologique des Quinzes Vingts
Paris, France
University of Bonn
Bonn, Germany
Augenklinik der LMU München
München, Germany
University of Tuebingen
Tübingen, Germany
Budapest Retina Institute
Budapest, Hungary
Semmelweis Egyetem
Budapest, Hungary
University of Debrecen DE KK Szemészeti Klinika
Debrecen, Hungary
Ganglion Medical Center
Pécs, Hungary
Szegedi Tudomanyegyetem, Szent-Gyorgyi Albert Klinikai Kozpont, Szemeszeti Klinika
Szeged, Hungary
Rambam Health Care Campus
Haifa, Israel
Hadassah University Hospital
Jerusalem, Israel
Rabin Medical Center, Beilinson campus
Petah Tikva, Israel
Kaplan Medical Center
Rehovot, Israel
Tel-Aviv Sourasky Medical Center, Ichilov Hospital
Tel Aviv, Israel
AOU Policlinico Sant'Orsola Malpighi, U.O. Oftalmologia,
Bologna, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, Italy
Ospedale San Raffaele
Milan, Italy
University of Campania Luigi Vanvitelli Eye Clinic
Naples, Italy
Fondazione Policlinico Tor Vergata, UOSD Patologie Retiniche
Rome, Italy
Institut de la Macula
Barcelona, Spain
Princess Alexandra Eye Pavillion
Edinburgh, United Kingdom
Moorfields Eye Hospital
London, United Kingdom