Clinical Research Directory

Inclusion Criteria: Subjects with Parkinson's Disease (PD) who are planning to have staged, bilateral deep brain stimulation surgery at the University of Colorado Hospital and willing and able to do the following: 1. Have a computer and be willing to use it as part of this study. 2. Be able to learn to use and maintain a wristband-style sleep monitor. 3. Turn off their Implantable Pulse Generator (IPG, implanted battery). 4. Wear a wristband-style sleep monitor for 3 weeks, 6 weeks prior to surgery. 5. Spend one overnight research stay in the UCH Sleep lab, 3 weeks prior to DBS surgery . 6. Spend one overnight research stay in the UCH Sleep lab, immediately prior to IPG surgery, to record brain activity from the DBS electrode . 7. Have a 15 minute surgery to externalize the DBS lead cable to allow overnight recordings to occur. 8. Be pseudo-randomized to one of 2 conditions: OFF stimulation or ON stimulation. 9. Wear a wristband-style sleep monitor for 3 weeks, 3 months post-DBS surgery, in one of the 2 pseudo-randomized conditions. 10. Spend one overnight research stay in the UCH Sleep lab, 4 months post DBS surgery, in one of the pseudo-randomized conditions. Subjects will have a sleep disorder documented in their medical history as determined by a single question screen for REM sleep behavior disorder. Exclusion Criteria: 1. Subjects with Parkinson's Disease (PD) who are not planning to have staged, bilateral deep brain stimulation surgery at the University of Colorado Hospital. 2. Subjects without a documented sleep disorder.