Clinical Research Directory

Inclusion Criteria: * Have progressive chronic kidney disease with an eGFR less than 15 ml/min/1.73m2 and a DIFE between 30-35 * Expected to commence maintenance hemodialysis as their renal replacement treatment * Agreeable to randomization Exclusion Criteria: * Acute kidney injury (AKI) or AKI on chronic kidney disease (CKD) * With the primary disease of systemic lupus erythematosus (SLE) or systemic vasculitis * Have received or planning to receive a kidney transplant or peritoneal dialysis during the study * Has a recently diagnosed cancer that was likely to affect survival (except for the following cases: the cancer has been confirmed to be cured or relieved for over 5 years, have had the radical resection for the basal cell carcinoma or squamous carcinoma of skin or carcinoma in-situ of any part of the body ) * Hepatocirrhosis * Positive test of Human Immunodeficiency Virus (HIV), the hepatitis B virus antigen (HBsAg) or anti-hepatitis C virus antibody (HCV Ab) * Acute infection within 1 month * Bad habit which is difficult to withdrawal such as alcohol abuse * Poor compliance and could not be treated according to the protocol * Being pregnant, nursing or having a plan for pregnancy * Life expectancy less than 1 year * The investigator confirm that should not enroll in the study with any other cases