Clinical Research Directory
Browse clinical research sites, groups, and studies.
Body Weight, Sleep, and Heart Health
Sponsor: Oregon Health and Science University
Summary
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity. Specifically, in a valid circadian protocol, the investigators aim to study resting cardiovascular risk markers and the reactivity of circadian rhythms in these risk markers to standardized stressors. It is intended to compare results in lean and obese individuals to determine if there are specific risks across the circadian cycle specific to obesity. Furthermore, using an exploratory approach, the investigators propose to explore impairment in pre/post synaptic function in the cardiac left ventricle.
Official title: Circadian Mechanisms of Cardiovascular Risk in Obesity
Key Details
Gender
All
Age Range
25 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
16
Start Date
2018-05-01
Completion Date
2026-06-30
Last Updated
2025-12-12
Healthy Volunteers
Yes
Interventions
Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
Drugs are used for as part of physiological monitoring and not as interventions, including imaging using radiopharmaceuticals (11C-meta-hydroxyephedrine, and 11C-CGP12177).
Locations (1)
Oregon Health & Science University
Portland, Oregon, United States