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ACTIVE NOT RECRUITING
NCT03399110
PHASE3

XELOX for 4 Months Versus 6 Months in Gastric Cancer (LOMAC)

Sponsor: Fudan University

View on ClinicalTrials.gov

Summary

Our study aims to compare the efficacy and safety of 4-month versus 6-month adjuvant chemotherapy with capecitabine and oxaliplatin following D2 gastrectomy in patients with gastric cancer. Hypothesis: In patients with gastric cancer who have undergone D2 gastrectomy, a 4-month regimen of capecitabine and oxaliplatin demonstrates noninferiority to a 6-month regimen in terms of disease-free survival (DFS) and safety.

Official title: XELOX for 4 Months Versus 6 Months as Adjuvant Chemotherapy in Gastric Cancer After D2 Resection (LOMAC)

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

1024

Start Date

2017-11-17

Completion Date

2026-07-25

Last Updated

2026-01-27

Healthy Volunteers

No

Conditions

Interventions

DRUG

Oxaliplatin

Oxaliplatin 130 mg/m2

DRUG

Capecitabine

Capecitabine 1000mg/m2

Locations (9)

Sun Yat-sen University Cancer Center

Guangzhou, China

The First Affiliated Hospital of Anhui Medical University

Hefei, China

The First Affiliated Hospital of University of Science and Technology of China

Hefei, China

Jiangsu Cancer Hospital

Nanjing, China

Changhai Hospital

Shanghai, China

Second Affiliated Hospital (Changzheng Hospital) of Naval Medical University

Shanghai, China

Shanghai East Hospital

Shanghai, China

13940152108@163.Com

Shenyang, China

The First Affiliated Hospital of Wannan Medical College

Wuhu, China