Clinical Research Directory

Inclusion Criteria: * Written informed consent * Male or female subject aged 18 years or more with no upper age limit and willing to comply with the protocol * Indication to a LAAC as indicated in study population (HAS BLEED ≥3 or High bleeding risk as defined by Munich consensus document and CHA2DS2-VASc≥2) Exclusion Criteria: * New York Heart Association class IV congestive heart failure * Atrial septal defect or atrial septal repair or closure device * Single occurrence of atrial fibrillation * Cardioversion or ablation procedure planned within 30 days * Implanted mechanical valve prosthesis * Heart transplantation * Enrolled in another IDE or IND investigation of a cardiovascular device or an investigational drug * Pregnant or pregnancy is planned during the course of the investigation * Active infection of any kind * Severe chronic kidney insufficiency (CrCl\< 30 ml/min) * Terminal illness with life expectancy \< 1 yr * Echocardiographic exclusion criteria * Left ventricular ejection fraction \< 20% * Intra-cardiac thrombus or dense spontaneous echo contrast as visualized by TEE within 2 days before implant * Significant mitral valve stenosis (ie, MV \<1.5 cm2) * Complex aortic atheroma with mobile plaque of the descending aorta and/or aortic arch * Cardiac tumor