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ET1 Concentration, Metabolic Pathway Activation, and Pulmonary Blood Flow in Infants Undergoing Superior Cavo-Pulmonary Anastomosis
Sponsor: University of Colorado, Denver
Summary
This is a novel preliminary study of biomarkers of pathologic pre-operative pulmonary vascular development, elevated pre-operative Pulmonary Vascular Resistance Index (PVRi), and complications associated with decreased post-operative pulmonary blood flow in single ventricle patients undergoing superior cavo-pulmonary anastomosis (SCPA). The study will utilize a combined targeted and untargeted approach to both optimize translation of a promising existing biomarker and efficiently identify novel biomarkers and potential therapeutic targets in this population.
Key Details
Gender
All
Age Range
1 Month - 2 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2018-02-10
Completion Date
2027-12-31
Last Updated
2026-05-01
Healthy Volunteers
Not specified
Conditions
Interventions
Research Blood Sampling
Blood samples will be collected at specified time points and research assays will be performed.
Locations (1)
Children's Hospital Colorado
Denver, Colorado, United States