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ACTIVE NOT RECRUITING
NCT03406338
PHASE4

Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease

Sponsor: Region Skane

View on ClinicalTrials.gov

Summary

This randomized controlled trial will compare the outcome of surgery (fasciectomy) with that of local injection of Collagenase Clostridium Histolyticum in patients with recurrent finger joint contracture after previous treatment with Surgery, collagenase injection or needle fasciotomy. Half of the participants will be treated with surgery while the other half will receive collagenase injection.

Official title: Surgical Fasciectomy Versus Collagenase Injection in Treating Recurrent Dupuytren Disease: a Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2018-03-20

Completion Date

2027-09

Last Updated

2025-04-16

Healthy Volunteers

No

Interventions

PROCEDURE

Fasciectomy

Surgical excision of Dupuytren cords causing finger joint contractures. Surgery done under regional or general anesthesia. Additional procedures (such as capsulotomy or skin graft) done if surgeon deemed necessary.

DRUG

Collagenase Clostridium Histolyticum

Injection of Collagenase into the Dupuytren cord after local anesthesia (nerve block) followed 24-48 hours later by finger manipulation after local anesthesia

Locations (1)

Department of Orthopedics Hässleholm-Kristianstad

Hässleholm, Sweden