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Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease
Sponsor: Region Skane
Summary
This randomized controlled trial will compare the outcome of surgery (fasciectomy) with that of local injection of Collagenase Clostridium Histolyticum in patients with recurrent finger joint contracture after previous treatment with Surgery, collagenase injection or needle fasciotomy. Half of the participants will be treated with surgery while the other half will receive collagenase injection.
Official title: Surgical Fasciectomy Versus Collagenase Injection in Treating Recurrent Dupuytren Disease: a Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2018-03-20
Completion Date
2027-09
Last Updated
2025-04-16
Healthy Volunteers
No
Conditions
Interventions
Fasciectomy
Surgical excision of Dupuytren cords causing finger joint contractures. Surgery done under regional or general anesthesia. Additional procedures (such as capsulotomy or skin graft) done if surgeon deemed necessary.
Collagenase Clostridium Histolyticum
Injection of Collagenase into the Dupuytren cord after local anesthesia (nerve block) followed 24-48 hours later by finger manipulation after local anesthesia
Locations (1)
Department of Orthopedics Hässleholm-Kristianstad
Hässleholm, Sweden