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Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Summary
Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
230
Start Date
2017-12-20
Completion Date
2033-06-23
Last Updated
2026-01-20
Healthy Volunteers
No
Conditions
Interventions
Collection of blood sample in aneurysm
In case of an endovascular treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure. * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit. In case of a surgery treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery. * A Tissue sample will be taken during the surgery * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.
Locations (1)
Fondation Ophtalmologique A. de Rothschild
Paris, France, France