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Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
Sponsor: University of Utah
Summary
This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells. After completion of cohort 1 (108 participants), the protocol was expended to add a second cohort of 80 additional participants, and re-opened study recruitment.
Official title: Short Course Adjuvant Vaginal Cuff Brachytherapy (VCB) in Early Endometrial Cancer Compared to Standard of Care (SAVE)
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
188
Start Date
2018-02-02
Completion Date
2029-10-31
Last Updated
2025-12-12
Healthy Volunteers
No
Conditions
Interventions
Vaginal Cuff Brachytherapy
Undergo standard of care vaginal cuff brachytherapy
Short course vaginal cuff brachytherapy
Undergo short course vaginal cuff brachytherapy
Locations (5)
Stanford Cancer Center
Palo Alto, California, United States
Loyola University Medical Center
Maywood, Illinois, United States
MD Anderson
Houston, Texas, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States
Intermountain Medical Center / LDS Hospital
Salt Lake City, Utah, United States