Clinical Research Directory

General Exclusion (both Dystonia and Control groups): * Metal in any part of the body (including metal injury to the eye) OR carrying a medical device incompatible with MRI (e.g., metal implants such as surgical clips or pacemakers) OR positive screening per UTSW MRI screening form * Claustrophobia * Non-fluent English * Weight incompatible with MRI safety * History of head trauma with neurological sequelae, including multiple concussions and/or history of stroke * Pregnancy * Serious medical illness or history of serious medical illness, including cancer that was treated with radiation or chemotherapy, heart attack, or a known history of HIV-1 + status * Subjects with Hepatitis C (by Hepatitis C+ titer) * Subjects with insulin dependent diabetes mellitus (IDDM) * Severe respiratory compromise * In the opinion of the investigator, not able to safely participate in this study Inclusion Criteria: * Dystonia group Previous diagnosis of dystonia which include but is not limited to: * cervical dystonia (50 subjects) * blepharospasm (25 subjects) * limb dystonia (50 subjects) * spasmodic dysphonia (25 subjects) * segmental dystonia * multi-focal dystonia * Any childhood-onset dystonia (25 subjects) Age \> 11 years * Control group: No prior dystonia diagnosis (175 subjects) Age \> 11 years Exclusion Criteria: * Dystonia group Prior history of or concurrent neurological or psychiatric diagnosis - depression and/or anxiety accepted Current use of non-dystonia neuroactive medications - SSRI/medication for depression and/or anxiety accepted Current use of cervical brace designed for dystonia treatment Prior structural brain injury Control group: History of or current neurological or psychiatric diagnosis - depression and/or anxiety accepted, but must not be in active phase Current use of any neuroactive medication, SSRI/medication for depression and/or anxiety accepted