Clinical Research Directory

Inclusion Criteria: 1. Age 65 years or older 2. Working diagnosis of vasodilatory hypotension as assessed by treating team 3. Vasopressors started for 12 hours or less (window from ICU admission after/during adequate fluid resuscitation as assessed by treating physician) 4. Vasopressors expected for 6 additional hours as assessed by the treating team Exclusion Criteria: 1. Actively treated for spinal cord injury or acute brain injury 2. Vasopressors being given solely for bleeding, acute ventricular failure or post-cardiopulmonary bypass vasoplegia 3. Lacking commitment to life-sustaining therapies (expected withdrawal of life-sustaining treatments within the next 48 hours 4. Death perceived as imminent 5. Previously enrolled in OVATION-65 6. Organ transplant within the last year 7. Extra corporeal life support at baseline 8. The treating physician(s) lacks equipoise regarding the overall effects of permissive hypotension versus usual care on patient important outcomes.