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TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery
Sponsor: University Hospital, Bordeaux
Summary
The aim is to assess the impact of tranexamic acid (TXA) for preventing postpartum hemorrhage (PPH) following a cesarean section (CS).
Official title: TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery :a Multicenter Randomised, Double Blind Placebo Controlled Trial (TRAAP2)
Key Details
Gender
FEMALE
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
4574
Start Date
2018-03-03
Completion Date
2020-04-08
Last Updated
2026-05-12
Healthy Volunteers
No
Conditions
Interventions
Tranexamic Acid Injectable Solution
After the routine and prophylactic administration of a uterotonic , the intervention will be the IV administration of a 10-ml blinded ampoule of the study drug (either TXA or placebo according to the randomisation sequence) to the woman within 3 minutes after birth, slowly (over 30-60 seconds), once the cord has been clamped.
Sodium Chloride 0.9%
After a routine and prophylactic administration of a uterotonic , the intervention will be the IV administration of a 10-ml blinded ampoule of the study drug (either TXA or placebo according to the randomisation sequence) to the patient within 3 minutes afterbirth), slowly (over 30-60 seconds), once the cord has been clamped.
Locations (26)
CHU Angers
Angers, France
CHU Jean Minjoz
Besançon, France
CHU Bordeaux
Bordeaux, France
CHRU Côte de Nacre
Caen, France
CHU Estain
Clermont-Ferrand, France
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Hôpital Saint Joseph Marseille
Marseille, France
Hopital Nord
Marseille, France
CHU de Montpellier
Montpellier, France
CHRU de Nancy
Nancy, France
CHU Nantes
Nantes, France
CHU Nîmes
Nîmes, France
Hôpital Trousseau
Paris, France
Hôpital Saint Joseph Paris
Paris, France
Maternité de Port-Royal Paris
Paris, France
Hôpital universitaire Necker-Enfants malades
Paris, France
Hôpital universitaire Robert Debré
Paris, France
Hôpital universitaire Kremlin-Bicètre
Paris, France
CH de Pau
Pau, France
Centre Hospitalier Intercommunal Poissy-Saint Germain
Poissy, France
CHU Rennes
Rennes, France
CHU Charles Nicolle
Rouen, France
CHU Saint Etienne
Saint-Etienne, France
CHU Strasbourg
Strasbourg, France
Hôpital Paule de Viguier CHU Toulouse
Toulouse, France
CHU Tours
Tours, France