Clinical Research Directory
Browse clinical research sites, groups, and studies.
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging
Sponsor: University of Leipzig
Summary
Aortic aneurysms represent the most common and dangerous aortic diseases. Although conventional aortic repair techniques cure the disease, there is a high risk of paraplegia particularly in extensive thoracoabdominal aneurysms due to impaired blood supply to the spinal cord. The PAPA-ARTiS trial will assess the clinical safety and efficacy of the MISACE (Minimally-Invasive Segmental Artery Coil-Embolization) procedure, a novel therapeutic concept to reduce the risk of paraplegia due to aneurysm repair. The study investigates the MISACE procedure as a potential pre-treatment prior to open or endovascular aneurysm repair in patients with thoracoabdominal aortic aneurysms. Patients will be randomized to one of the two treatment strategies: a) aneurysm repair without MISACE pre-treatment, or b) aneurysm repair with MISACE pre-treatment.
Official title: Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging With 'Minimally-Invasive Segmental Artery Coil-Embolization': A Randomized Controlled Multicentre Trial - PAPAartis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2018-11-08
Completion Date
2025-06
Last Updated
2024-04-11
Healthy Volunteers
No
Conditions
Interventions
Minimally-Invasive Segmental Artery Coil-Embolization
During one single MISACE session 3-7 segmental arteries will be occluded. The procedure is conducted through a peripheral artery access in local anaesthesia. Microcoils or vascular plugs will be used for the occlusion itself.
Locations (29)
Medizinische Universität Innsbruck
Innsbruck, Austria
Herzzentrum Hietzing
Vienna, Austria
University Hospital of Bordeaux
Bordeaux, France
Marie Lannelongue Hospital
Le Plessis-Robinson, France
Uniklinik RWTH Aachen
Aachen, Germany
Deutsches Herzzentrum Berlin
Berlin, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, Germany
Westdeutsches Herz und Gefäßzentrum Essen
Essen, Germany
Universitäts-Herzzentrum Freiburg/ Bad Krozingen
Freiburg im Breisgau, Germany
Herzzentrum Hamburg
Hamburg, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitätsklinikum Heidelberg
Heidelberg, Germany
Herzzentrum Leipzig
Leipzig, Germany
UniversitätskIinikum Leipzig
Leipzig, Germany
Klinikum rechts der Isar (TU München)
Munich, Germany
Klinikum der Universität München (LMU)
München, Germany
Universitätsklinikum Münster
Münster, Germany
Paracelsus Universität - Klinikum Nürnberg
Nuremberg, Germany
Universitätsklinikum Regensburg
Regensburg, Germany
Universitätsklinikum Tübingen
Tübingen, Germany
S.Orsola-Malpighi Hospital
Bologna, Italy
Ospedale San Raffaele SRL
Milan, Italy
Maastricht University Medical Center
Maastricht, Netherlands
Medical University of Warsaw
Warsaw, Poland
Silesian Center for Heart Diseases
Zabrze, Poland
Lund University Hospital Malmoe
Malmo, Sweden
Örebro University Hospital
Örebro, Sweden
Bern University Hospital
Bern, Switzerland
St Bartholomews Hospital
London, United Kingdom