Clinical Research Directory

Inclusion Criteria: OCD subjects: * The subject has a minimum score of ≥16 on the Y-BOCS; * If applicable, on a stable pharmacologic regimen; * Sample will be enriched with OCD subjects having contamination obsessions and handwashing compulsions, and scores on items 9 and 10 of the Y-BOCS reflecting difficulty resisting and controlling compulsions; Healthy Control Subjects: * Men and women will be age/gender matched with subjects * Absence of any psychiatric disorder determined by the MINI\^53 for DSM-5 with the exception of non-impairing specific phobia. * Low scores on measures of contamination concerns and disgust sensitivity based on Y-BOCS scores below 10 and the Disgust Scale-Revised (total score \<8). Exclusion Criteria: OCD Subjects: * Subject has a documented lifetime diagnosis of psychotic disorders such as schizophrenia; * Alcohol or substance abuse/dependence reported within 6 months, excluding nicotine; * The subject is deemed at high risk of suicidal behavior or impulsivity. The Beck Depression Inventory\^52 (BDI) will be completed by all subjects and responses reviewed by a clinician. Healthy Control Subjects: \- Those not meeting the inclusion criteria described in the inclusion section above.