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Multiparametric MRI for Diagnosing Small Renal Tumors
Sponsor: University Hospital, Bordeaux
Summary
Renal cell carcinoma represents annually 3-5% of all new cancer diagnoses. To date, the standard of care for small renal masses is partial nephrectomy. However, in the specific setting of small renal masses, 20% of them are benign and surgery results in overtreatment. Non-invasive techniques able to differentiate the inherent characteristics of tumors (nature, aggressiveness) would be useful to offer the most appropriate therapeutic options. Morphological ultrasound or CT imaging appeared limited because of the lack of discriminatory power. Based on the data of retrospective studies, the hypothesis is that multiparametric (mp) MR parameters using chemical shift, diffusion and/or contrast injection techniques may be a reproducible diagnostic test with sufficient diagnostic accuracy to differentiate benign from malignant renal tumors. The originality of this project lies in the opportunity to simultaneously assess the performance of mpMRI in diagnosing renal tumors in a routine clinical practice in 18 centers. In each center, two independent MRI readings performed by two radiologists will be carried out within a short delay and interpreted blind to each other's results or pathological results using a predefined template. A third reading will also be centrally performed by the coordinating center according to similar modality. All clinical, radiological and pathological data will be collected after anonymization in the UroCCR database. These informations are used to adjust the therapeutic decision and selecting patients eligible for nephrectomy, other therapeutic options or monitoring.
Official title: Diagnostic Value of Multiparametric MR Imaging of Small Solid Renal Tumors (IRMK01)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
387
Start Date
2018-11-27
Completion Date
2023-04-14
Last Updated
2026-05-14
Healthy Volunteers
No
Conditions
Interventions
Multiparametric MR imaging (mpMRI)
The main objective of the study is to assess the diagnostic accuracy of mpMRI in small renal tumors. The study characteristics will comply with recommended methods (Quadas, Stard). The population to be included will be representative of patients who would benefit from mpMRI if it is demonstrated to be accurate. In this project, the MR protocol will used the conventional MR sequences either on 1.5 or 3T systems and do not require development. Each center may use their own protocol as long as it includes the mandatory sequences.
Locations (18)
CHU Angers
Angers, France
CHU Bordeaux
Bordeaux, France
APHP - Henri Mondor
Créteil, France
CHU de Grenoble
Grenoble, France
APHP - Hôpital Bicêtre
Le Kremlin-Bicêtre, France
CHRU Lille
Lille, France
CHU Lyon
Lyon, France
APHM - Hôpital de la Conception
Marseille, France
CHU Nancy
Nancy, France
CHU Nice
Nice, France
APHP - Hôpital Tenon
Paris, France
APHP - Hôpital Necker
Paris, France
APHP - Hôpital Bichat
Paris, France
CHU Rennes
Rennes, France
CHU Rouen
Rouen, France
CHU Strasbourg
Strasbourg, France
CHU Toulouse
Toulouse, France
CHU Tours
Tours, France