Clinical Research Directory
Browse clinical research sites, groups, and studies.
Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
Sponsor: Northwestern University
Summary
Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term. One of the most distressing immediate complications of this severe perineal injury is perineal pain. Women can also experience postpartum depression, dyspareunia, and altered sexual function after OASIS. This is a randomized controlled trial to study the effects of three interventions (placebo, low dose intravenous ketamine plus epidural morphine, or epidural morphine alone) on acute pain after OASIS. The objective of this study is to assess the incidence of perineal pain in postpartum patients 1 week after obstetric anal sphincter injuries.
Official title: Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries: A Randomized Clinical Trial
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
67
Start Date
2018-06-27
Completion Date
2024-06-20
Last Updated
2026-04-24
Healthy Volunteers
No
Conditions
Interventions
Epidural saline + IV saline
Sterile saline injection in the epidural catheter and in the intravenous catheter
Epidural morphine 3 mg + IV saline
Morphine 3 milligrams injection in the epidural catheter and sterile normal saline intravenous catheter
Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
Morphine 3 milligrams injection in the epidural catheter and 0.3 milligrams per kilogram weight infused in the intravenous catheter
Locations (1)
Northwestern University
Chicago, Illinois, United States